Studies on Endothelial Permeability. IV

[摘要] In the preceding paper evidence has been presented which points to the fact that in canine anaphylaxis the endothelium, particularly that of the liver, plays a very prominent rôle in the mechanism of shock. Indeed it might seem that the chief point of attack of the reinjected protein is in this tissue, and that after these cells have been injured and become more permeable the liver is the next organ to be affected. The whole phenomenon is a vascular shock rather than a neuro-muscular one such as we see in the guinea pig. This by no means excludes the possibility that toxic products may arise secondarily from the liver, as Manwaring (1) has contended; or that the mobilization of proteolytic enzymes, which has been previously demonstrated (2) may not act in producing toxic products from the disintegrating liver or other tissue cells.

[学科分类] 生物科学（综合）