Antigenicity of the M Proteins of Group A Hemolytic Streptococci

[摘要] Highly purified M proteins have excellent antigenic capacities in rabbits when administered in the form of repository subcutaneous doses with adjuvants. Both mineral oil and peanut oil emulsions prepared with Arlacel A and as little as 10 µg of M protein, after two or three injections, stimulated type-specific protective antibodies. Small doses of M proteins adsorbed to aluminum hydroxide were equally efficacious preparations for vaccine purposes. The attributes of these immunization procedures are discussed in terms of a practical antistreptococcal vaccine for human use. The globulin nature of the antibodies induced in rabbits immunized with purified M proteins or whole bacterial cells was also investigated. Both types of antigenic stimulation induced IgG antibodies but with different precipitating and hemagglutinating capacities.

[学科分类] 生物科学（综合）