Antigenicity of Polypeptides (Poly-Alpha-Amino Acids)

[摘要] Chemically modified derivatives of the copolymer of glutamic acid and lysine and/or alanine were prepared and studied for immunogenic and immunochemical properties. Deamination of G60L40 enhanced the immunogenicity for rabbits but not for guinea pigs. Modification of the carboxylate groups of G60A40 reduced considerably its immunogenicity for both species. The deaminated block GL and poly GAG of known sequence were very poor immunogens, possibly because of insufficient complexity in structure. Also, the importance of an appropriate concentration of free polyglutamate sequences for immunogenic activity has been mentioned as a possible explanation for these findings in rabbits.

[学科分类] 生物科学（综合）