Studies on Anaphylactic Shock in the Mouse

[摘要] 1. 1. A report is made on the effects of x-irradiation (500 r) on the anaphylactic response of mice sensitized with bovine albumin-adjuvant emulsion and challenged with bovine albumin solution.2. 2. X-irradiation given 1/12, 2, 4, 6 or 8 days before or 2, 4 or 6 days following sensitization failed to enhance the anaphylactic sensitivity when the interval between sensitization and challenge was 7 days.3. 3. X-irradiation given 1/12, 2, 4, 6, 8, 10, 12 or 14 days before or 2, 4, 6 or 8 days after sensitization depressed the anaphylactic sensitivity of mice challenged 10 days after sensitization as measured by mortality incidence and changes in rectal temperatures.4. 4. In general, a depressive effect of x-irradiation on the anaphylactic response was observed in mice exposed 2, 4, 6, 8 or 10 days prior to or 2 days following sensitization when challenge was made 14, 21, 28, 35 or 42 days postsensitization.5. 5. An enhancement of susceptibility to fatal anaphylaxis was discernible in sensitized animals receiving x-irradiation 4 days or more following sensitization when the interval between sensitization and challenge was 14, 21 or 28 days. No effect of x-ray on mortality incidence or change in rectal temperature was observed when the interval was 35 or 42 days.

[学科分类] 生物科学（综合）