Mixed Bacterial Infections in Relation to Antibiotic Activities

[摘要] 1. 1. In mixed peritoneal Shigella paradysenteriae-Escherichia coli infections of adult mice it has been shown that an antibiotically active E. coli will cause a reduction in the shigellae concomitantly with the in vivo secretion of antibiotic. When the E. coli partner of the mixed infection was nonantibiotic, both the shigellae and the E. coli flourished in the peritoneal cavity.2. 2. In contrast to this finding, in the oral infection of newborn mice with a lethally virulent E. coli strain, there was no apparent difference in the slightly reduced mortality rates obtained when the pathogen was given in combination with an antibiotically active or a nonactive E. coli strain.3. 3. This failure of the antibiotic E. coli to clearly protect against enteric infection in the second experimental model, was observed in spite of the fact that implantation of this strain (534) in the intestinal tract of newborn mice was demonstrated to be quite overwhelming4. 4. Newborn animals of two mouse strains (CF1 and CFW) were found to differ significantly in their susceptibility to lethal enteric infection with an enteropathogenic Escherichia coli strain (18A10).

[学科分类] 生物科学（综合）