Alterations in Serum Lysozyme and Properdin Titers of Mice Following X-Irradiation or Treatment with Zymosan or Endotoxin

[摘要] Inoculation of mice with Zymosan or endotoxin caused an initial decline and subsequent rise in lysozyme titers that was similar but not identical with changes in properdin titer. Mice responded to irradiation with progressively decreasing lysozyme levels whereas properdin titers rose to above normal shortly after irradiation and then fell to normal or below normal levels. The serum lysozyme titer in mice thus appeared to be a more consistent indicator in irradiation damage than the properdin titer.Lysozyme could not be substituted for properdin in vitro for the lysis of paroxysmal nocturnal hemoglobinuria erythrocytes, tannic acid treated erythrocytes, toxoplasmacidal activity or for the inactivation of C′3. A lysozyme depleted serum (RL) containing complement and properdin possessed full activity in these systems.

[学科分类] 生物科学（综合）