The Effect of Iodination on Antibody Activity

[摘要] The effect of extent of iodination on antibody activity was studied in the following systems: a ) the specific precipitation of antiovalbumin and of antibovine serum albumin, b) the localizing activity of antikidney antibody c ) the binding activity of antierythrocyte antibody. In each system the antibody activity is decreased rapidly with iodination; 30-iodine atoms per antibody molecule essentially destroy activity. The destruction is interpreted as being due to preferential iodination of a particular group, probably tyrosine, in the antibody specific site. Iodination below 2 atoms/molecule does not affect antibody activity of antibodies requiring only one site for activity, i.e. , localizing, binding, or hemolytic antibodies.

[学科分类] 生物科学（综合）