A Study of the Mechanism of the Anticomplementary Activity of γ-Globulin

[摘要] 1. 1. Human γ-globulin causes a marked decrease in the C′1 and C′4 activity of guinea pig complement. This anticomplementary activity is enhanced by heating the γ-globulin at 56–60°C or by adsorbing it to bentonite.2. 2. The inactivation of C′4 in serum occurs only in the presence of C′1.3. 3. Following incubation with a source of C′1, a suspension of bentonite with adsorbed γ-globulin is capable of inactivating C′4 in serum fractions lacking C′1. This ability is abolished by the treatment of the suspension with diisopropyl-fluorophosphate.4. 4. It is suggested that the reaction of γ-globulin with complement is similar to the first steps of complement fixation by an antigen-antibody complex.

[学科分类] 生物科学（综合）