Effect of Dehepatization on Erythrocyte Anaphylaxis in Dogs

[摘要] In a previous paper (1) it was shown that the latent period between the intravenous injection of antigen into hypersensitive dogs and the resulting precipitous fall in arterial blood pressure is much shorter in erythrocyte anaphylaxis than in serum anaphylaxis. In serum anaphylaxis this latent period is usually about forty-five seconds, the time necessary for the transmission of the foreign protein to the hypersensitive liver, the formation or liberation of histamine-like[1][1] substances by this organ, and their subsequent transmission to the secondary reacting tissues of the body. In erythrocyte anaphylaxis the latent period is usually about fifteen seconds. It seems evident, therefore, that the characteristic precipitous fall in arterial blood pressure in erythrocyte anaphylaxis does not depend upon preliminary hepatic reactions, but is due to immediate reactions in certain extra-hepatic tissues. We have endeavored to test this conclusion by evisceration and dehepatization. [1]: #fn-1

[学科分类] 生物科学（综合）