Some Causes of Variation in the Laboratory Interpretation of Complement Fixation by Different Methods

[摘要] The observations reported in this paper have been emphasized by their recurrence in several studies of the complement fixation test in which we had the coöperation of other laboratories.In 1922 we made a study of the Kolmer (1) (2) standard method for complement fixation test as an aid to the diagnosis of syphilis, in coöperation with the laboratories of New York University and of New York Hospital. We had difficulty in drawing conclusions from those comparison tests because of the different criteria for interpretation of the two methods employed by the coöperating laboratories.In 1925 we participated in the work of the American Public Health Association Committee on Standardization of the Wassermann Test. Here, again, we had to take into consideration various criteria for interpretation before an accurate comparison could be made of the tests by the different laboratories.

[学科分类] 生物科学（综合）