Pasteurella Avicida Vaccination by the Oral, Subcutaneous, and Intravenous Methods

[摘要] Subcutaneous vaccination is more effective than oral vaccination in stimulating the production of typhoid agglutinins in rabbits (1). It is questionable which method is more effective in stimulating the production of immunity. Besredka believes that agglutinins and other specific antibodies in the blood stream are practically negligible as factors in immunity (2). He believes that immunity is cellular and in order to produce a “solid” immunity, the vaccine must be applied directly to the body ceils. This immunity appears, in certain cases, within twenty-four hours. If Besredka is correct, current conceptions of immunity and methods of immunization will have to be modified.Calmette (3), and Enlows (4) have reviewed the evidence concerning oral vaccination. Sufficient data regarding the comparative efficiency of oral, subcutaneous, and intravenous methods of vaccination in stimulating the production of immunity are not available.The experiments described in this paper were designed to compare: ( a ) The production of agglutinins for Past. avicida in the blood of chickens and rabbits following oral, subcutaneous, and intravenous administrations of vaccine; and, ( b ) the resistante of the vaccinated animals to intravenous inoculations of Past. avicida.

[学科分类] 生物科学（综合）