Local Organ Hypersensitiveness

[摘要] The injection of small amounts of a foreign protein into the anterior chamber of the rabbit's eye produces an altered reaction capacity in this organ. After an appropriate incubation period the intravenous injection of the same antigen results in a transitory inflammatory response in the prepared eye. This was first demonstrated by Kummel (1), Fuchs and Meller (2), Von Szily (3) and by Riehm (4). Seegal and Seegal (5) studied the phenomenon, using a number of different antigens and established certain facts from which they inferred that the inflammatory eye response was the result of an antigen antibody reaction. The three main reasons for such a conclusion were: ( a ) an incubation period of at least five days is necessary before the reaction in the eye can be demonstrated. ( b ) The reaction is highly specific since only the protein injected into the eye will produce the local response on subsequent intravenous injection.

[学科分类] 生物科学（综合）