The Production of Proliferation Inhibitory Factor (PIF) by Mouse Spleen Cells in Vitro

[摘要] Concanavalin A and phytohemagglutinin stimulate mouse spleen cells to elaborate proliferation inhibitory factor (PIF) into their culture supernatants. As has been previously described for human PIF, murine PIF is cytostatic in the absence of cytotoxicity and is species-specific. Murine spleen cells, incubated with Escherichia coli lipopolysaccharide, undergo DNA synthesis but do not appear to make PIF.

[学科分类] 生物科学（综合）