The Use of Allogeneic T Lymphocytes and Bacterial Lipopolysaccharide to Induce Immune Responses to Monovalent Haptens in Vitro

[摘要] Immune responses to monovalent haptens were stimulated in mouse spleen cultures either by the addition of bacterial lipopolysaccharide (LPS) or by T cells reactive against the alloantigens on precursor antibody-forming cells (P-AFC). These findings suggest that P-AFC require two independently delivered signals for the induction of antibody synthesis. One signal is delivered via the interaction of hapten with surface immunoglobulin receptors. A second signal is delivered either by LPS or via the interaction of a T cell with cell surface determinants on P-AFC.

[学科分类] 生物科学（综合）