International Reference Preparation for Human Serum IgG, IgA, IgM

[摘要] International Reference Preparations for serum IgG, IgA, and IgM have been available for the past few years; their contents are indicated in International Units (I.U.). Estimates of the weight of the immunoglobulin corresponding to one I.U. have shown considerable variation when carried out in different laboratories. This is why it has previously been recommended that serum immunoglobulin concentrations estimated by comparison with the International Reference Preparation be expressed in International Units per milliliter (1). However, International Units have not gained general acceptance for clinical use. Therefore, we now recommend that human serum immunoglobulin concentrations continue to be estimated relative to the International Reference Preparation but that the values may be calculated in terms of weight based on the best available estimates (2).On this basis, the following are the weights of immunoglobulins corresponding to one I.U., and the concentrations of immunoglobulins in a solution prepared by dissolving the contents of one ampule of the International Reference Preparation by the addition of 1 ml of distilled water.

[学科分类] 生物科学（综合）