IgD: A Major Immunoglobulin on the Surface of Lymphocytes from Patients with Chronic Lymphatic Leukemia

[摘要] Previous studies on the characterization of surface immunoglobulins of lymphocytes from CLL[2][1] patients indicated that the cell-associated immunoglobulin was monoclonal with respect to heavy and light chain class with IgM being by far the most common Ig class observed (1–4). Our earlier study of CLL involved analysis for the presence of IgG, IgA, and IgM. Some cases were observed in which neither heavy nor light chains were detectable and others in which only light chains could be detected (1). A more detailed investigation of one of these patients demonstrated IgD as the major Ig class associated with these cells. We have accordingly evaluated other unselected cases of CLL for the presence of IgD on the lymphocyte surface. The current report details these studies and the relationship of IgD to IgM on the surface of CLL lymphocytes.Methods. Lymphocytes were obtained from patients with CLL having white blood counts ranging from 20,000 to 200,000 cells/mm3. [1]: #fn-2

[学科分类] 生物科学（综合）