The Allogeneic Effect: Increased Cellular Immune and Inflammatory Responses

[摘要] It has been previously shown that infusion of allogeneic lymphoid cells into primed inbred guinea pigs produces an augmentation of humoral immune responses. In this communication we have investigated the effects of such treatment on host cellular immune and inflammatory responses. Dinitrophenyl (DNP) ovalbumin- or DNP-bovine serum albumin-primed strain 2 guinea pigs received infusions of strain 13 guinea pig lymphoid cells. Six days later the recipients were challenged with the priming antigen intradermally. These “allogeneic” guinea pigs displayed larger delayed hypersensitivity skin reactions than did “control” guinea pigs which had been primed but had not received allogeneic lymphoid cells. The in vitro migration of peritoneal exudate cells from allogeneic guinea pigs was inhibited by antigen to a greater extent than was the migration of control peritoneal exudate cells. In addition, allogeneic guinea pigs displayed larger Arthus reactions than did control guinea pigs at a time when both the total serum and the IgG2 immunoglobulin DNP-lysine binding capacity were virtually identical for allogeneic and control guinea pigs. Also, both passive Arthus reactions and croton oil skin responses were greater in allogeneic guinea pigs. Thus, the transient graft-vs-host reaction induces both enhanced host thymus-derived lymphocyte function and inflammatory responses.

[学科分类] 生物科学（综合）