The Inactivation of Human C1 by Benzamidine and Pyridinium Sulfonylfluorides

[摘要] Affinity chromatographically purified C1̄ was demonstrated to be inhibitable by a variety of benzamidine and pyridinium fluorosulfonyl-substituted compounds. Four of the compounds tested afforded greater than 50% inhibition at concentrations between 10-6 and 10-5 M. The data indicated that inhibition was greatest with those compounds which contained a substituted benzamidine and sulfonyl-fluoride group. The site of action was the esterase activity associated with the C1.

[学科分类] 生物科学（综合）