Effect of Anti-µ-Specific Immunosuppression on Friend Virus Leukemia

[摘要] Evidence is presented that neonatally initiated immunosuppression of BALB/c mice with rabbit anti-µ antiserum renders them refractory to Friend virus leukemia. Mice so treated failed to develop typical leukemic leukocytosis, splenomegaly, or splenic foci upon injection of 2.2 LD50 doses of Friend leukemia virus. A brief regimen of anti-µ treatment in young adult mice was shown to depress moderately the immune response against sheep red blood cells but to have no discernible effect upon the development of Friend virus leukemia. Several possible explanations for these observations are discussed.

[学科分类] 生物科学（综合）