Chemical and Immunological Studies of the Pneumococcus

[摘要] From type I pneumococcus cells a specific substance, apparently carbohydrate in nature, was isolated. Its properties and antigenic activity are described as follows: 1. 1. Precipitation occurred with type I antipneumococcus serum in a dilution of 1:6,000,000; also, in a dilution of 1:600,000 with type I antipneumococcus serum from which the antibodies against the specific carbohydrate of Heidelberger and Avery had been adsorbed.2. 2. Complement was fixed in the presence of type I antipneumococcus rabbit serum.3. 3. Protein tests were negative and carbohydrate, positive.4. 4. Mice immunized with it were protected against type I pneumococcus infection.5. 5. It caused fatal anaphylactic shock in guinea pigs passively sensitized with type I antipneumococcus rabbit serum; also, in guinea pigs passively sensitized with type I antipneumococcus rabbit serum from which the antibodies against the specific carbohydrate of Heidelberger and Avery had been absorbed.

[学科分类] 生物科学（综合）