The Antigenic Properties of Fibrinogens

[摘要] Previous publications (1) (2) from this laboratory have pointed out the inadequacy of the usual methods of blood defibrination in preparing fibrinogen-free serum and particular methods have been given by which such a serum may be obtained. The fact has also been established that traces of fibrinogen in a serum profoundly modify the immune reactions of that serum both in vivo and in vitro , provoking shock reactions in the former and pseudoprecipitin and agglutinin reactions in the latter.Continuing the study of fibrinogen in relation to immune reactions we have recently tested the antigenic properties of fibrinogen and this paper presents evidence that the injection of foreign fibrinogen into an animal induces the production of antibodies specific for the particular fibrinogen used.The fibrinogen chiefly employed in our experiments was prepared from well developed Plymouth Rock cockerels.

[学科分类] 生物科学（综合）