Comparative Study of the Anaphylactic and Tuberculin Types of Hypersensitiveness

[摘要] The crystalline egg albumin and egg globulin differ considerably in their relationship to the different manifestations of hypersensitiveness. The crystalline egg albumin tends to sensitize the organism to those manifestations of the hypersensitiveness which are mediated by antibodies. The egg globulin tends to sensitize to those in which the active immunization plays the more important rôle. The difference between the antigens lies in their capacity to produce a different type of sensitization. We find no marked difference between them concerning their capacity to produce antibodies or to elicit the reactions themselves. The observations with crystalline egg albumin and egg globulins present an analogy to the behavior of certain bacterial antigens which we usually find connected either with the tuberculin or with the anaphylactic type of sensitiveness.We have given a short review of our experiences concerning the capacity of different antigens to produce the tuberculin type of skin sensitiveness. With all innocuous antigens which we tested—as eggwhite and animal sera—we succeeded in producing this sensitiveness. With bacterial antigens we have not so far succeeded in producing it.

[学科分类] 生物科学（综合）