Therapy of Experimental Brucella Infection in the Developing Chick Embryo

[摘要] Previous reports have described a method for the evaluation of therapeutic agents against experimental Brucella infection, utilizing the developing chick embryo (1, 2, 3). Data comparing the relative effectiveness of sulfadiazine and streptomycin, individually and in combination, against infections in the chick embryo with each of the three species of Brucella have shown a definite synergism of these two agents when administered together.The early reports of Pulaski and Amspacher (4, 5), Eisele and McCullough (6), and those from this Clinic (7, 8), have demonstrated the marked advantage of combined therapy with streptomycin and sulfadiazine in human brucellosis over previous methods of therapy. But this form of treatment possesses certain disadvantages. Because streptomycin must be injected intramuscularly, and because the antibiotic is potentially toxic, hospitalization of patients is essential. In addition to the expense of treatment and the threat of toxic reactions, relapses have occurred following the cessation of treatment.

[学科分类] 生物科学（综合）