Antibodies to Denatured Desoxyribonucleic Acid in a Lupus Erythematosus Serum

[摘要] The reaction between the serum of a patient with disseminated lupus erythematosus and DNA has been studied by quantitative complement fixation. Thermally denatured DNA was shown to be a more reactive antigen than native DNA. Immunologic measurement of melting out and renaturation of the antigen characterized it as DNA. DNase-digested antigen preparations failed to react but were effective inhibitors. Lupus erythematosus (LE) serum detected serologic differences in denatured DNA preparations from various sources.

[学科分类] 生物科学（综合）