The in Vivo Production of Penicillinase by Hemolytic Staphylococcus Aureus

[摘要] The production of staphylopenicillinase has been demonstrated in vivo . The sterilized homogenate of mouse kidneys when placed in wells on agar plates seeded with Sarcina lutea showed penicillinase activity. This activity was seen only in strains that were naturally penicillin resistant. This was not an adaptive enzyme, as it was present in the absence of penicillin exposure. Penicillinase was not present immediately after infection in mouse kidneys, but required time for production.

[学科分类] 生物科学（综合）