Skin Sensitizing Antibodies: A Comparative Study of Canine and Human PK and PCA Antibodies and a Canine Myeloma Protein

[摘要] Canine reaginic antibody from 13 atopic animals with hypersensitivity to ragweed pollens has been separated from other canine immunoglobulins, including the γM-globulins, a canine polymeric (10 S) myeloma protein and a canine γG-antibody eliciting a passive cutaneous anaphylactic (PCA) reaction in the guinea pig, by Sephadex G 200 gel filtration and sucrose density gradient ultracentrifugation. The canine reaginic antibody also has been compared with atopic human reaginic antibody, human isohemagglutinins with intermediate sedimentation coefficients, human anti-tetanus toxoid (PCA) antibody and pathologic human immunoglobulins, and has been found to be closely similar in size to the human reaginic antibody.The ability of canine reaginic antisera to elicit a dermal anaphylactic Prausnitz-Küstner reaction was markedly reduced after exposure to 2-mercaptoethanol.

[学科分类] 生物科学（综合）