THE DIAGNOSIS AND TREATMENT OF GENERALIZED CYTOMEGALIC INCLUSION DISEASE OF THE NEWBORN

[摘要] 1. A case of cytomegalic inclusion disease of the newborn is reported. The incidence, etiology, pathology, clinical and laboratory findings, differential diagnosis, prognosis and treatment are discussed.2. This is the fourth case of cytomegalic inclusion disease diagnosed prior to death, and the second case which is still living.3. Any infant with the following features may be considered as a possible case of cytomegalic inclusion disease: (a) Prematurity; (b) evidence of erythroblastosis with jaundice, hemolytic anemia, reticulocytosis, and an increasing serum bilirubin with a negative Coombs test; (c) thrombopenia with bleeding manifestations; and (d) hepatosplenomegaly.4. The finding of cytomegalic inclusion cells in the urine confirms the diagnosis.5. The importance of making a presumptive diagnosis of cytomegalic inclusion disease within the first 24 to 36 hours of life has been emphasized since exchange transfusion may be the initial treatment of choice.6. Cortisone is apparently of value in suppressing the hemolytic process and in improving the thrombopenia. Gamma globulin may be of value in milder cases which do not receive exchange transfusion.In conclusion, we now have methods of diagnosing and treating cytomegalic inclusion disease of the newborn; a disease which has usually been fatal and, presumptively, is caused by the salivary gland virus. The infection apparently occurs during intrauterine life. Further viral diagnostic studies must be made to clarify the etiology and pathogenesis of this clinically new viral disease.

[学科分类] 儿科学