BILIRUBIN ENCEPHALOPATHY

[摘要] (1) Staining of the brain can be produced in normal newborn white rats by intraperitoneal injection of a solution of bilirubin.(2) Under similar conditions it was not possible to produce staining of the brain in a comparable series of normal adult rats.(3) This study further emphasizes the importance of the immaturity of the organism in the production of hyperbilirubinemia and its consequent passage through the "bloodbrain barrier" (Bilirubin Encephalopathy).(4) This adds to the increasing evidence that immaturity of biochemical and physiological processes determines the pathological states which appear to be unique to the newly born organism.

[学科分类] 儿科学