ANTIBODY RESPONSES TO NATURALLY OCCURRING POLIOMYELITIS INFECTIONS IN CHILDREN

[摘要] Serums collected over an 18-month period from children with a clinical diagnosis of poliomyelitis were studied by means of the complement fixation test. Test antigens were prepared from the nutrient fluid of tissue cultures infected with each of the 3 known types of poliomyelitis viruses. Results were compared with those obtained from neutralization tests on the same serums. The complement fixation test was of little diagnostic help in these patients; a high titer, a rise in titer, and a fall in titer were all inconstant findings. A complement fixing antibody titer persisting beyond 100 days was more indicative of the immunologic type of the infecting virus than any other feature of the complement fixing antibody response.The multitypic nature of the complement fixing antibody response was discussed in relation to the complex antigenic structure of poliomyelitis viruses.

[学科分类] 儿科学