SUBCUTANEOUS ADMINISTRATION OF A SULFADIAZINE-SULFAMERAZINE COMBINATION IN CHILDREN

[摘要] The feasibility of intermittent subcutaneous administration of a sulfadiazine-sulfmerazine combination (2.5% aqueous solutions of the sodium salts in equal amounts) in infants and children was evaluated by means of absorption-excretion and therapeutic studies.In 60 children with acute infections, intermittent injections of this combination at 12 hour intervals on the basis of 0.13 gm./kg. to 0.2 gm./kg. in 24 hours, gave excellent and well sustained blood and urine levels of sulfonamide and resulted in a highly satisfactory therapeutic response. No local reactions were encountered in more than 500 individual injections.The incidence of systemic toxicity from the sulfadiazine-sulfamerazine combination was lower than that reported in similar treatment with either compound employed separately. Renal complications, in particular, appear substantially decreased despite the omission of adjuvant alkali therapy. Only one sensitization reaction was observed in this series.Because of its local irritant effect, the subcutaneous administration of sodium sulfathiazole is not recommended.Subcutaneous therapy with a combination of sodium sulfadiazine and sodium sulfamerazine has a definite place in the treatment of the infant and small child. The combination seems preferable to single sulfonamides because of a distinctly lower toxicity. These findings confirm our previous studies with oral administration of sulfonamide mixtures.

[学科分类] 儿科学