THE USE OF PENICILLIN IN OIL AND WAX IN CHILDREN

[摘要] Penicillin in oil and wax was administered to 106 infants and children in a total of 510 single injections at 24 hour intervals as therapy for acute infections. The Clinical response was comparable to that seen with aqueous penicillin administered at more frequent intervals. From this study the following conclusions were reached.1. The danger of local reaction is not great, as in only five cases there appeared urticarial lesions near the site of injection which seemed to cause no discomfort and which deared within 48 hours. There were no more serious reactions.2. There is no satisfactory correlation between the size of dose per unit of body weight and the resulting blood level of penicillin 24 hours after injection. There is, however, a relation between the absolute dose and the resulting blood level. A dose of 300,000 units in all patients regardless of size produced a satisfactory level for the control of ordinary infections.3. Both sodium and potassium salts were used. There is doubtful statistical evidence that the potassium salt produces higher levels at the end of 24 hours.

[学科分类] 儿科学