USE OF I131-LABELED PROTEIN IN THE STUDY OF PROTEIN DIGESTION AND ABSORPTION IN CHILDREN WITH AND WITHOUT CYSTIC FIBROSIS OF THE PANCREAS

[摘要] A method is described for evaluating protein digestion and absorption by measuring the fecal excretion of isotope after the administration of a test meal of I131-labeled protein. Application of this method to 10 children without gastrointestinal disase and to five with cystic fibrosis of the pancreas revealed the following:1. Less than 6% of the ingested isotope was excreted in the feces of the "control" subjects.2. A 10 to 40% (av. 22.5%) fecal excretion of the ingested isotope occurred in the children with cystic fibrosis of the pancreas.3. A 50% decrease in the fecal excretion of isotope resulted in 2 of 4 children with cystic fibrosis of the pancreas when pancreatin was fed with the test meal.4. One patient with cystic fibrosis of the pancreas, who after receiving pancreatin still excreted 40% or more of the ingested isotope in the feces, excreted only 8% when the test was repeated with prehydrolyzed protein.

[学科分类] 儿科学