COAGULATION STUDIES IN THE NEWBORN INFANT

[摘要] Data on the whole blood clotting time, platelet count, prothrombin concentration, protamine titration and gross observation for clot lysis are presented on 21 normal newborn infants within six hours of birth, and on the third and fifth days of life.The whole blood clotting time within the first six hours of life ranged from 7 to 38 minutes with an average of 14 minutes. On the third day of life the range was from 10 to 60 minutes with an average of 25 minutes. On the fifth day of life the range was from 6 to 38 minutes with an average of 16 minutes.Protamine titration was increased as compared to normal adult values in 6 of 26 infants within the first six hours of life. On the third day 7 of 26 showed an increase. All titrations were normal on the fifth day.The prothrombin concentration showed all variations of patterns, the average pattern being high on the first day, lower on the third day, and high on the fifth day.Platelet values for the three days studied were all within normal limits, for adults.Further data on 35 normal newborn infants, studied in groups of five through the first seven days of life using the above technics with the addition of the heparin sensitivity test, are presented.The significance of the data is discussed.

[学科分类] 儿科学