New Observations in Generalized Cytomegalic-Inclusion Disease of the Newborn: Report of a Case with Chorioretinitis

[摘要] A case of cytomegalic-inclusion disease occurring in the newborn period is reported. This particular infant had chorioretinitis and intracranial calcifications very similar to what is found in toxoplasmosis. The provisional diagnosis of toxoplasmosis was not discounted until the Sabin-Feldman dye test was found to be negative. Typical inclusions in cells characteristic of cytomegalic-inclusion disease were found in the urine and gastric washings. A virus was grown in tissue culture from specimens of urine and aqueous humor. This virus isolate was similar to, if not identical with, the salivary gland virus—the presumed cause of cytomegalic-inclusion disease. Neutralizing antibodies were demonstrated to be present in the patient's serum against a virus recovered from another case of this disease.

[学科分类] 儿科学