HERPANGINA: CLINICAL AND LABORATORY ASPECTS OF AN OUTBREAK CAUSED BY GROUP A COXSACKIE VIRUSES

[摘要] The causal relationship between certain Coxsackie group A viruses and the disease entity herpangina first reported by Huebner and his associates in 1951 is confirmed.Outbreaks of herpangina in Philadelphia during the summer of 1951 are described.Coxsackie group A viruses of three different immunologic types were isolated from stools or throat swabs, or both, obtained from 17 of the 21 patients involved in the outbreaks.A rise in complement-fixing and neutralizing antibody titers against homologous virus strains during convalescence was demonstrated in 3 patients.Asymptomatic carriers of Coxsackie group A virus are described. Evidence is presented suggesting that two children with herpangina acquired their infection from such a carrier.The criteria used in making a laboratory diagnosis of infection with Coxsackie virus are discussed.

[学科分类] 儿科学