HYPERKALEMIC FAMILIAL PERIODIC PARALYSIS

[摘要] The clinical histories of three families are described, who have a variant of familial periodic paralysis characterized by high concentration of potassium during paralytic episodes unassociated with diminished urinary excretion of potassium. Data are presented concerning five hospitalized patients from the three families. The data indicate that the rise in concentration of potassium in serum results from a shift of potassium into the extracellular phase. During the recovery period potassium travels in the opposite direction.The administration of glucagon or epinephrine during an acute attack terminated the attack promptly. The administration of 10 to 15 mg of dextro-amphetamine sulfate daily in Spansule® form effectively controlled symptoms in two patients, and resulted in definite improvement in a third patient, treated for periods varying from 3 to 7 months.

[学科分类] 儿科学