NEONATAL THYROTOXICOSIS

[摘要] Two cases of congenital goiter with severe thyrotoxicosis are described. In one instance, unusual tachycardia was noted in utero. The mothers, treated before conception with radioactive iodine and thyroidectomy, respectively, were, at the time of delivery, not only thyrotoxic, but markedly exophthalmic.Treatment of the infants with Lugol's solution intravenously and orally, with the addition of propylthiouracil in one case, resulted in a return to normal after a few weeks.Appraisal of the pathogenesis of neonatal thyrotoxicosis favors the transplacental passage of a thyroid-stimulating agent, probably derived from the mother's pituitary.The thyroid status of neonates born of mothers taking medication for thyrotoxicosis reflects the interaction between the transmitted thyroid-stimulating agent and the particular drug being employed.

[学科分类] 儿科学