已收录 273170 条政策
 政策提纲
  • 暂无提纲
HYPERBILIRUBINEMIA OF NEWBORN INFANTS ASSOCIATED WITH THE PARENTERAL ADMINISTRATION OF A VITAMIN K ANALOGUE TO THE MOTHERS
[摘要] Seven cases of marked hyperbilirubinemia occurring among premature infants within the first 40 to 72 hours of life are reported. The mothers of these infants had received 72 mg of a vitamin K analogue (Hykinone®) intramuscularly or intravencusly from 2 to 112 hours prior to delivery. The evidence presented indicates that this medication predisposed the infants to hyperbilirubinemia.The hypothesis is presented that the vitamin K analogue passed through the placenta and exerted a hepatotoxic effect upon the newborn infant. Because of possible serious consequences to the infant, new drugs should be used with caution when administered to pregnant women or to newborn infants, and medications should be given in doses no larger than necessary to obtain a desired and proven therapeutic or prophylactic effect.
[发布日期]  [发布机构] 
[效力级别]  [学科分类] 儿科学
[关键词]  [时效性] 
   浏览次数:2      统一登录查看全文      激活码登录查看全文