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EXPERIMENTAL PRODUCTION OF CONGENITAL CLEFT PALATE: GENETIC AND ENVIRONMENTAL FACTORS
[摘要] Experimental studies and theoretic considerations on the problem of palate closure and the ways it may fail have led to the following conclusions:The process of palate closure involves the delicate integration of a number of processes, each under the influence of genetic and environmental factors. These processes include the building up of a force within the palatine shelves enabling them to overcome the resistance of the tongue and meet in the mid-line, provided the width of the head and the width of the shelves are appropriate.The process of palate closure can go wrong in a number of ways, each of which may result in a cleft palate: (a) the intrinsic shelf force may be impaired, e.g., by fetal and maternal genes and by cortisone; (b) the resistance of the tongue may be increased, e.g., by the mechanical stresses on the embryo following amniotic puncture; (c) the head may be too wide to allow the palatine shelves to meet in the mid-line; (d) the shelves may be too narrow to meet in the mid-line.Obviously it is useless to argue about whether cleft palates are genetically or environmentally determined, or to attempt to find any one cause or cure that will account for all of them. Nevertheless our efforts to clarify the situation are justified, as each etiological factor that is understood may allow some reduction in the frequency of this defect.
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[效力级别]  [学科分类] 儿科学
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