THE ADRENOGENITAL SYNDROME, SALT-LOSING TYPE

[摘要] Case reports of two brothers with the adrenogenital syndrome, followed from birth to the ages of 7 and 5 6/12 years, respectively, are presented.Virilism and addisonian crises were prevented with fair success in both by cortisone and DOCA.Along with reduction of urinary output of androgens, growth was moderately retarded, but when cortisone dosage was lowered output of androgens increased and marked acceleration of growth, including skeletal maturation, occurred.An episode of hypertension occurred in each case, but was preceded and followed by periods of normal blood pressure. These episodes may have been due to accelerated release of desoxycorticosterone from implanted DOCA pellets.

[学科分类] 儿科学