TOLERANCE OF INFANTS AND CHILDREN TO FAT ADMINISTERED INTRAVENOUSLY

[摘要] One hundred forty-six intravenous infusions of fat emulsions were given to 78 infants and children. In 15 subjects receiving 3 to 6 infusions on successive days, no significant changes occurred in concentration of nonprotein nitrogen, bilirubin or alkaline phosphatase in the serum; the cephahin flocculation test, concentration of urobilinogen in the urine and routine urinalysis were not abnormal. Three instances of increased values in the zinc turbidity test were noted. Four infants developed mild anemia.During infusions administered at an average rate of 5 ml/kg/hr for periods of 4 to 6 hours, concentrations of ketones in the blood increased an average of 7.1 mg/100 ml (1.2 mM/l) in non-fasted subjects and 13.2 mg/100 ml (2.3 mM/l) in fasted subjects. This is interpreted as suggestive evidence of utilization of fat during the infusion.Temperature elevations of more than 1.1°C (2°F) occurred during or after the infusion in 23.9% of infusions with a marked increase in frequency at infusion rates greater than 5 ml/kg/hr. Vomiting occurred in 12.3%. Other unfavorable reactions were uncommon.

[学科分类] 儿科学