CYSTIC FIBROSIS HETEROZYGOTE RESISTANCE TO CHOLERA TOXIN IN THE CYSTIC FIBROSIS MOUSE MODEL

[摘要] The authors propose that the widespread distribution of cystic fibrosis may reflect an underlying benefit to heterozygous individuals for CFTR mutations via increased resistance to secretory diarrhea. Ironically, in the homozygous state, CFTR disfunction leads to increased infection with a variety of respiratory and other pathogens, thus negating any benefit to human homozygotes.

[学科分类] 儿科学