The Role of Tocopherol in Oxygen-Induced Retinopathy: Kitten Model

[摘要] The effect of tocopherol (vitalnin E) on oxygen-induced retinopathy was studied in 75 kittens following the development of a 12-point scoring system to quantitate the degree of retinopathy seen at three weeks. The tocopherol was found to be beneficial when given daily from the day of birth ( P < .0001) with oxygen exposures of two to three days (79% F1O2) beginning on day 3. Caution is urged in applying these data to humans because (1) hepatosplenomegaly was noted in the treated animals, and (2) the kitten model of oxygen-induced retinopathy is not entirely satisfactory,

[学科分类] 儿科学