Vaccination against herpes group viruses

[摘要] The development of viral vaccines, like everything else, becomes more complicated with time. Success has been spectacular with vaccines against viral infections such as polio, measles, and rubella. The factor common to this success has been the protective effect of humoral antibody together with (in some cases) antibody secreted on mucosal surfaces. Now virologists are turning their attention towards the herpesvirus group, which presents problems not previously met.The new problems may be summarized as follows:(1) The possible oncogenicity of human herpesviruses . Several herpesviruses of animals have been shown beyond reasonable doubt to be oncogenic in homologous or heterologous species. These include the Lucké virus of frogs,1 the Herpesvirus saimiri of squirrel monkeys (oncogenic in other primates),2 and the Marek's virus of chickens.3

[学科分类] 儿科学