VITAMIN A POISONING

[摘要] Two cases of hypervitaminosis A have been presented together with a review of experimental and clinical literature.The first case presented the highest reported fasting plasma vitamin A level, the increase being chiefly due to a high vitamin A alcohol fraction. This elevated level of alcoholic vitamin A probably denotes large stores of vitamin A in the liver and data have been given to show that it is a better index of hypervitaminosis A than is the total vitamin A level. In addition, evidence has been presented that the toxic factor in hypervitaminosis A is the permanent elevated plasma vitamin A level.The similarity between the experimental studies in animals and the observations in the authors' first case has been shown.The important points necessary for making a diagnosis of hypervitaminosis A have been discussed and several similar conditions have been differentiated.It cannot be emphasized too strongly that excess vitamin intake may be as dangerous as a deficient intake.

[学科分类] 儿科学