RELATIVE EFFECTIVENESS OF VITAMINS A AND D IN OIL AND IN WATER

[摘要] When small doses of vitamin A (1, 2, 3 or 10 units) in water solution, emulsion or oil solution were fed to vitamin A-deficient rats, their gain in weight and the improvement of xerophthalmia were equal at comparable dosage levels.When single doses (14, 28, 56, 84 or 140 units) of the same three vitamin solutions were given to vitamin A-deficient rats, there was again no difference in the average gain in weight or survival of comparable groups.The liver storages of vitamin A after feeding graded amounts of the vitamin to vitamin A-deficient rats were equal for the water and oil solutions at comparable dosage levels of 10, 20 and 40 units. At higher dosages the water solution resulted in larger storage than the oil solution.The antiricketic effectiveness of calciferol, activated 7-dehydrocholesterol, and a mixture of vitamin D as in fish liver oil was the same irrespective of whether the vitamin was supplied in water or in oil.The data are interpreted to mean that the rapid absorption, or greater liver storage, that results from large doses of water solutions of vitamin A is of no consequence at dosage levels required to quantitate therapeutic effect.

[学科分类] 儿科学