AUREOMYCIN IN THE TREATMENT OF EXPERIMENTAL AND CLINICAL INFECTIONS WITH H. INFLUENZAE, TYPE B

[摘要] Aureomycin, in doses of 20 mg./kg. body weight, was as effective in the treatment of mice infected with H. influenzae, type B, as streptomycin and dihydrostreptomycin, and more effective than polymyxin or Q-19.Two infants with H. influenzae, type B, meningitis were treated successfully with aureomycin and sulfadiazine. Spinal fluid cultures became negative and marked clinical improvement occurred within 48 hours. Both patients went on to complete recovery. Three children were treated with aureomycin alone. Although their response to treatment was not so rapid as that of the infants treated with aureomycin and sulfadiazine, rccovery was assured within four to seven days and subsequently there were no evidences of residual damage. No serious toxic reactions to aureomycin were apparent.A sixth patient, desperately ill on admission, succumbed within 36 hours in spite of adequate treatment with combined aureomycin and sulfadiazine.

[学科分类] 儿科学