LONG BONE INVOLVEMENT IN SICKLE CELL ANEMIA

[摘要] Two types of pathologic changes may occur in the long bones of patients with sickle cell anemia. A hyperplastic bone marrow represents the response to continued destruction of erythrocytes and this produces a wide medullary cavity and a thin cortex. The thromboses of vessels in the marrow and bone result in abnormal areas of calcification and new bone formation producing a thick cortex and a small medullary cavity. The findings on roentgenographic examination will depend upon which of the two processes is dominant.A 21 month old Negro infant whose symptoms of sickle cell anemia began at 4 months of age showed typical roentgenographic findings resulting from a hyperplastic marrow. The cortex in the femur had become so thin that a pathologic fracture resulted. This is the first reported instance of the occurrence of a pathologic fracture in sickle cell anemia.

[学科分类] 儿科学