EXPERIMENTAL CARCINOGENESIS WITH IRON-DEXTRAN

[摘要] Two Articles in this issue of Pediatrics report on the use of an iron-dextran complex (Imferon), a preparation which, on April 25, 1960, was withdrawn from the American market. This action was taken by the distributor, Lakeside Laboratories, upon recommendation of the Food and Drug Administration and followed publication of experiments which demonstrated the induction of sarcomas in mice and rats at the sites of repeated injections of the drug. In view of the extensive clinical use of Imferon in recent years it seems appropriate to review critically the evidence for the possible carcinogenicity of the preparation and the justification for its removal from the market.

[学科分类] 儿科学