A NEW REPOSITORY PENICILLIN (A FORM OF AQUEOUS PENICILLIN G PROCAINE) IN INFANTS AND CHILDREN

[摘要] Eighty-two children with a variety of infectious diseases were treated with a daily injection of a new repository penicillin, aqueous penicillin G procaine (Abbott).Clinical success was obtained in 68 of 75 patients. In one, the results were considered fair, in three poor, and in three unknown.Thirty-five patients had a beta Str. hemolyticus, and 10 a pneumococcus isolated from the nose or throat. Bacteriologic success was obtained in all streptococcal infections, but in only 6 of 10 pneumococcal infections.All of the streptococci were sensitive to penicillin when tested by in vitro methods.Penicillin serum levels with a mean maximum of approximately 2 u./ml. were observed at two hours, and mean minimum of approximately 0.063 u./ml. at 24 hours. The curve of intermediate values approximated a normal curve.

[学科分类] 儿科学